cath tools

Protein structure comparison tools such as SSAP and SNAP

UCLOrengoGroup
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10
C++

CATH Tools Build Status Documentation Status

Overview

Protein structure comparison tools such as SSAP, as used by the Orengo Group in curating CATH.
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  		Code
  		Extras repo
 

Tools
cath-cluster
Complete-linkage cluster arbitrary data.
cath-map-clusters
Map names from previous clusters to new clusters based on (the overlaps between) their members (which may be specified as regions within a parent sequence). Renumber any clusters with no equivalents.
cath-resolve-hits
Collapse a list of domain matches to your query sequence(s) down to the non-overlapping subset (ie domain architecture) that maximises the sum of the hits’ scores.
cath-ssap
Structurally align a pair of proteins.
cath-superpose
Superpose two or more protein structures using an existing alignment.

Extra Tools

  • build-test Perform the cath-tools tests (which should all pass, albeit with a few warnings)
  • cath-assign-domains Use an SVM model on SSAP+PRC data to form a plan for assigning the domains to CATH superfamilies/folds
  • cath-refine-align Iteratively refine an existing alignment by attempting to optimise SSAP score
  • cath-score-align Score an existing alignment using structural data

Authors

The SSAP algorithm (cath-ssap) was devised by Christine A Orengo and William R Taylor.

Please cite: Protein Structure Alignment, Taylor and Orengo, Journal of Molecular Biology 208, 1-22, PMID: 2769748. (PubMed, Elsevier)

Since then, many people have contributed to this code, most notably:

Acknowledgements

cath-ssap typically uses DSSP, either by reading DSSP files or via its own implementation of the DSSP algorithms.

cath-cluster uses Fionn Murtagh’s reciprocal-nearest-neighbour algorithm (see Multidimensional clustering algorithms, volume 4 of Compstat Lectures.
Physica-Verlag, Würzburg/ Wien, 1985. ISBN 3-7051-0008-4) as described and refined in Daniel Müllner’s Modern hierarchical, agglomerative clustering algorithms (2011, arXiv:1109.2378).

Feedback

Please tell us about your cath-tools bugs/suggestions here.

If you find this software useful, please spread the word and star the GitHub repo.